11/22/2023 0 Comments Antidote warfarinPlus, as a synthetic small molecule, PER977, unlike biologics such as PRT064445 in its current form, is stable at room temperatures. If you have something that's going to work regardless, that gives a physician a lot more confidence in applying it.” “When someone comes into an emergency room, they might not know exactly what they're on. That broad action provides a major advantage, says Solomon Steiner, chief executive of the company. Meanwhile, Perosphere, a startup headquartered in the suburbs of New York, has an antidote drug called PER977 that might reverse the activity of all the new oral anticoagulation drugs-both the factor Xa and factor IIa inhibitors-as well as certain forms of heparin. In December, at the American Society of Hematology meeting in Atlanta, company scientists presented preclinical data showing that treatment with an experimental antibody fragment against Pradaxa resulted in safe and rapid reversal of blood loss in rats. For example, Boehringer Ingelheim, the German company behind Pradaxa (dabigatran), a blood thinner approved since 2010 that inhibits factor IIa (also known as thrombin), is developing its own antidote in house. Other anticoagulation antidotes are nearing clinical testing, too.
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